Key: Win : Draw : Loss
| Date | Home | Away | Ref | ||
|---|---|---|---|---|---|
| 04/08/2018 | Port Vale | 3 | 0 | Cambridge | T Kettle |
| 11/08/2018 | Colchester | 2 | 0 | Port Vale | M Donohue |
| 18/08/2018 | Port Vale | 1 | 0 | Crawley Town | P Marsden |
| 21/08/2018 | Carlisle | 2 | 1 | Port Vale | B Toner |
| 25/08/2018 | Tranmere | 1 | 0 | Port Vale | D Whitestone |
| 01/09/2018 | Port Vale | 1 | 2 | Newport County | M Coy |
| 08/09/2018 | Forest Green | 1 | 1 | Port Vale | A Young |
| 15/09/2018 | Port Vale | 2 | 0 | Northampton | T Bramall |
| 22/09/2018 | Crewe | 0 | 1 | Port Vale | D Drysdale |
| 29/09/2018 | Port Vale | 1 | 1 | Exeter | S Stockbridge |
| 02/10/2018 | Port Vale | 0 | 2 | Milton Keynes Dons | R Joyce |
| 06/10/2018 | Grimsby | 2 | 0 | Port Vale | A Haines |
| 13/10/2018 | Port Vale | 2 | 6 | Lincoln | B Huxtable |
| 20/10/2018 | Oldham | 0 | 1 | Port Vale | P Wright |
| 23/10/2018 | Stevenage | 0 | 0 | Port Vale | C Breakspear |
| 27/10/2018 | Port Vale | 1 | 0 | Bury | A Young |
| 03/11/2018 | Port Vale | 2 | 2 | Notts County | L Swabey |
| 17/11/2018 | Mansfield | 1 | 0 | Port Vale | M Coy |
| 24/11/2018 | Port Vale | 0 | 1 | Swindon | P Wright |
| 27/11/2018 | Yeovil | 0 | 3 | Port Vale | L Collins |
| 08/12/2018 | Morecambe | 2 | 2 | Port Vale | A Haines |
| 15/12/2018 | Port Vale | 2 | 2 | Cheltenham | G Salisbury |
| 22/12/2018 | Macclesfield | 0 | 0 | Port Vale | D Drysdale |
| 26/12/2018 | Port Vale | 0 | 1 | Grimsby | B Toner |
| 29/12/2018 | Port Vale | 1 | 4 | Oldham | P Marsden |
| 01/01/2019 | Lincoln | 1 | 1 | Port Vale | P Wright |
| 12/01/2019 | Port Vale | 0 | 3 | Colchester | S Oldham |
| 19/01/2019 | Crawley Town | 0 | 1 | Port Vale | D Whitestone |
| 26/01/2019 | Port Vale | 0 | 1 | Carlisle | C Breakspear |
| 29/01/2019 | Newport County | 0 | 0 | Port Vale | N Hair |
| 09/02/2019 | Cambridge | 1 | 0 | Port Vale | S Stockbridge |
| 16/02/2019 | Port Vale | 0 | 1 | Morecambe | J Busby |
| 19/02/2019 | Port Vale | 1 | 2 | Tranmere | C Hicks |
| 23/02/2019 | Cheltenham | 1 | 0 | Port Vale | P Wright |
| 02/03/2019 | Notts County | 0 | 0 | Port Vale | C Hicks |
| 09/03/2019 | Port Vale | 2 | 1 | Mansfield | D Bond |
| 12/03/2019 | Port Vale | 3 | 0 | Yeovil | G Eltringham |
| 16/03/2019 | Swindon | 0 | 0 | Port Vale | D Drysdale |
| 23/03/2019 | Port Vale | 0 | 2 | Forest Green | P Marsden |
| 30/03/2019 | Northampton | 1 | 2 | Port Vale | N Hair |
| 06/04/2019 | Port Vale | 1 | 0 | Crewe | A Davies |
| 13/04/2019 | Exeter | 2 | 0 | Port Vale | T Nield |
| 19/04/2019 | Port Vale | 1 | 4 | Stevenage | N Kinseley |
| 22/04/2019 | Milton Keynes Dons | 1 | 1 | Port Vale | A Young |
| 27/04/2019 | Port Vale | 0 | 1 | Macclesfield | C Boyeson |
| 04/05/2019 | Bury | 1 | 1 | Port Vale | E Ilderton |